APAP Overdose
نویسندگان
چکیده
منابع مشابه
Targeted metabolomic profiling indicates structure-based perturbations in serum phospholipids in children with acetaminophen overdose
Phospholipids are an important class of lipids that act as building blocks of biological cell membranes and participate in a variety of vital cellular functions including cell signaling. Previous studies have reported alterations in phosphatidylcholine (PC) and lysophosphatidylcholine (lysoPC) metabolism in acetaminophen (APAP)-treated animals or cell cultures. However, little is known about ph...
متن کاملHigh mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity
BACKGROUND Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Necrotic tissue releases high mobility group B1 (HMGB1), and HMGB1 contributes to liver injury. Even though blockade of HMGB1 does not protect against APAP-induced acute liver injury (ALI) at 9 h time point, the later time points are not studied and the role of HMGB1 in APAP overdose is unknown, it is possible that ne...
متن کاملMetabolomics Analysis of Urine Samples from Children after Acetaminophen Overdose
Acetaminophen (APAP), a commonly used over-the-counter analgesic, accounts for approximately fifty percent of the cases of acute liver failure (ALF) in the United States due to overdose, with over half of those unintentional. Current clinical approaches for assessing APAP overdose rely on identifying the precise time of overdose and quantitating acetaminophen alanine aminotransferase (ALT) leve...
متن کاملThe Effect of Rebadioside A on Attenuation of Oxidative Stress in Kidney of Mice under Acetaminophen Toxicity
Background: Acetaminophen (APAP) overdose causes renal and hepatic injury. It is also believed that oxidative stress has a pivotal role in APAP-induced renal injury. Therefore, protective effects of different antioxidants have been examined in APAP-induced renal and hepatic toxicity models. Stevia rebadiana is a plant with a high degree of natural antioxidant activity in its leaf extract. T...
متن کاملEffects of Curcumin Attenuated Hepatitis in Mice with Paracetamol Overdose
Background: N-acetyl-p-aminophenol (APAP) or paracetamol overdose causes increasing of toxic metabolites, which disrupting hepatocyte function, and liver injury occurs. Curcumin has been used for treatment of inflammatory conditions such as hepatitis. Therefore, this study aims to determine effects of curcumin attenuate hepatitis in mice with APAP overdose. Methods: Male mice (25-30 gram) were ...
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ژورنال
عنوان ژورنال: MedEdPORTAL
سال: 2007
ISSN: 2374-8265
DOI: 10.15766/mep_2374-8265.522